Martin A. Janich1, 2, Rolf F. Schulte2, Steffen J. Glaser1, Dirk Mayer3, 4
1Department of Chemistry, Technische Universitt Mnchen, Munich, Germany; 2GE Global Research, Munich, Germany; 3Neuroscience Program, SRI International, Menlo Park, CA, United States; 4Department of Radiology, Stanford University, United States
The combination of constant-time point-resolved spectroscopy (CT-PRESS) with optimized broad bandwidth refocusing pulses (S-BURBOP) improved the signal detection of homonuclear coupled spins by reducing the chemical-shift displacement error. The signals of Lactate, Glutamate, and Glutamine were significantly increased in evaluations in a phantom and in healthy volunteers.