Bhavana Shantilal Solanky1, Frank Riemer1, Claudia A. M. Wheeler-Kingshott1, Xavier Golay2
1NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom
Partial volume effects and the high intensity of the CSF signal may lead to inaccuracies in the determination of 23Na concentrations in peri-ventricular regions (Peri-V). With this in mind we tested two methods of suppressing the CSF signal to enable a more accurate quantification of total 23Na in Peri-V tissue: An inversion recovery (IR) sequence to eliminate CSF based on exploiting T1 relaxation differences between CSF and tissue a dual echo sequence exploiting the difference in T2 relaxation. These methods were compared in terms of residual CSF signal and the resultant effect of CSF contamination in Peri-V regions was assessed