Fast and Selective MRI of Xenon Biosensors

Martin Kunth¹, Jrg Dpfert¹, Christopher Witte¹, Federica Rossella¹, Leif Schrder¹

Concepts of biosensor detection by MRI are of actual interest, since its non-ionizing radiation property. This study demonstrates single-shot localization of functionalized ¹²⁹Xe as used in specific biosensors in low concentration. Cryptophane-A was used in different surroundings to simulate two different types of biosensors at concentrations of 10M each, seperated by 1.2 ppm. Our technique employs presaturation and EPI encoding on hyperpolarized (HP) ¹²⁹Xe. This fast imaging limits the Hyper-CEST technique to the HP Xe delivery process to the cryptophane-A cages and turns out to be promising for biosensor detection even in the nanomolar range.