Abstract #1639

Passively Masked Surface Charge of SPIO Nanoparticles for Specific Detection of EGFR Expressing Tumor Cells

Yun-Ming Wang¹, Shou-Cheng Wu², Jia-Gong Lin

¹Department of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan; ²Department of Biological Science and Technology, National Chiao Tung University, Taiwan

In this study, a facile approach for the passive masking of non-conjugated reactive amine groups on the surface of iron oxide nanoparticles is demonstrated. The usefulness of this strategy has been exemplified by EGFR specific MR-optical imaging agent (SPIO-mAb-FITC NPs). The TEM and confocal image shows that the passive masking of reactive groups enhances the targeting efficacy of the imaging agent.