Samuel A. Hurley1, Do P. Tromp2, Marina E. Emborg1, 3, Sachiko Ohshima-Hosoyama3, Martin Brady4, Raghu Raghavan4, Ken Kubota5, Andrew L. Alexander1, 6
1Medical Physics, University of Wisconsin, Madison, WI, United States; 2Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, United States; 3Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, United States; 4Therataxis, Baltimore, MD, United States; 5Kinetics Foundation, Los Altos, CA, United States; 6Psychiatry, University of Wisconsin, Madison, WI, United States
Convection enhanced delivery (CED) is a method for targeted drug delivery to the brain with a uniform concentration and limited spatial extent. We present a quantitative T1 mapping approach to track infusion progress and concentration without the need for T1-shortening contrast agents, which contain heavy metals and may put patients at higher risk for Parkinson's disease progression.