Stephanie L. Barnes1, 2, Jennifer G. Whisenant2, 3, Gregory D. Ayers4, Thomas E. Yankeelov1, 2
1Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 2Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, United States; 3Chemical and Physical Biology, Vanderbilt University, Nashville, TN, United States; 4Cancer Biostatistics, Vanderbilt University, Nashville, TN, United States
MRI techniques have been developed that have the potential to evaluate the response of tumors to treatment in a more sensitive manner than physical change in tumor size. However, confident implementation of these methods for tumor evaluation requires knowledge of their repeatability. The focus of this work is the evaluation of the repeatability of DCE-MRI in mice. Both 1282 and 642 acquisition matrices were evaluated, with 642 consistently demonstrating higher repeatability. Specifically in the 642 case, a statistically significant change in Ktrans and ve for a group of 12 mice is 7.3% and 3.9%, respectively.