Barbara Janssen1, Nicoline Voet2, Rob Arts1, Christine Nabuurs1, George Padberg3, Alexander Geurts2, Baziel van Engelen3, Arend Heerschap1
1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2Rehabilitation, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 3Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands
To assess natural progression towards a diseased state in FSHD-patients, and effects of Cognitive Behavioral Therapy and Aerobic Exercise Training (AET) we used muscle fraction measured by 1H-MRI of the thigh muscles as non-invasive biomarkers. A decrease in muscle fraction, corresponding to an increase in fatty infiltration, could be noticed in controls after a four month period of usual care. This increase was largest in intermediate affected muscles. Interventions appeared to beneficial to patient since no significant increase in fat infiltration could be noticed after four months after intervention, heavily affected muscles even showed an increase in muscle fraction.