Alexandra R. Morgan1, 2, Geoff JM Parker1, 2, Tim F. Cootes1, 2, Marietta LJ Scott3, Josephine H. Naish1, 2
1Imaging Science, School of Cancer and Enabling Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, Greater Manchester, United Kingdom; 2Biomedical Imaging Institute, The University of Manchester, Manchester, Greater Manchester, United Kingdom; 3AstraZeneca R&D, Alderley Park, Macclesfield, United Kingdom
Current diagnosis methods in lung disease are not capable of examining local pathological changes in respiratory dynamics and mechanical properties. We have developed a method for investigating regional lung motion in 3D using proton magnetic resonance imaging (MRI). A mesh-based group-wise affine image registration was utilised, in conjunction with rapid structural lung imaging, to produce maps of local lung motion in expiration. The method presented here is illustrated in healthy volunteers.