Feng Zhao1, Min Deng1, Jing Yuan1, Queenie Chan2, Jun Yu3, Yi-Xiang Wang1
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 2Philips Healthcare, Hong Kong; 3Department of Medicine and therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong
Liver T1rho relaxation became prolonged after bile duct ligation-induced liver injury in rats has been reported. In this study, the liver of male Sprague-Dawley rats treated with carbon tetrachloride (CCl4) were scanned by T1rho and T2 weighted imaging at baseline, 2 days, 2 weeks, 4 weeks, 6 weeks post CCl4 injection. Liver T1 value increased slightly on day 2, increased further during the following weeks and was the highest at week 6 post insults. Relative liver signal intensity change on T2 weighted images followed a different time course.