Octavia Biris1, 2, Sanjiv J. Shah3, Michael J. Cuttica4, Jeremy D. Collins1, James C. Carr1, Timothy J. Carroll1
1Radiology, Northwestern University, Chicago, IL, United States; 2Biomedical Engineering, Northwestern University, Evanston, IL, United States; 3Feinberg School of Medicine/Cardiology, Northwestern University, Chicago, IL, United States; 4Feinberg School of Medicine/Pulmonary and Critical Care, Northwestern University, Chicago, IL, United States
We show proof-of-principle quantification of pulmonary artery pressure wave forms in patients with pulmonary arterial hypertension, by a three element Windkessel model with phase contrast MRI flow, MRI measured compliance, vascular resistance, characteristic impedance and mean pulmonary arterial pressure as inputs. To increase the resolution of the systolic pressure, we up-sample the flow input to a desired temporal resolution, by Fourier deconvolution with a boxcar function. The pressure wave forms obtained from the three element Windkessel and the up-sampled flow wave form are compared to pressure wave forms obtained by the two element Windkessel, with no re-sampling of flow data.