Donnie Cameron1, David Higgins2, Baljit Jagpal1, Margaret Bruce1, Nishat Siddiqi1, Christian Stehning3, Michael Frenneaux1, Thomas Redpath1, Dana Dawson1
1The University of Aberdeen, Aberdeen, Scotland, United Kingdom; 2Philips Healthcare, Guildford, United Kingdom; 3Philips Research, Hamburg, Germany
Modified Look-Locker Inversion recovery (MOLLI) is a useful tool for measuring T1 values in the myocardium. We applied MOLLI to acute myocardial infarction and acute tako-tsubo cardiomyopathy in order to assess its ability to distinguish normal myocardium from abnormal myocardium. Comparing two patient groups with healthy volunteers, MOLLI showed significant differences in T1 values of infarcted segments as compared to normal segments(p<0.005). Tako-tsubo dyskinetic segments demonstrated significantly higher T1 values than both normal and infarcted myocardium (p<<0.0001 versus normal). These results show that MOLLI sensitively delineates abnormal myocardium and provides superior evaluation compared to T2-weighted assessment.