Mingming Huang1, Lifeng Gao2, Liqin Yang2, Hao Lei3
1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences,, Wuhan, Hubei, China; 2State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences,, Wuhan, Hubei, China; 3State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, , Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences,, Wuhan, Hubei, China
Type 1 diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (STZ). High resolution brain anatomical images were acquired with a RARE sequence. And this study was performed on a 7T scanner to monitor the brain anatomical changes induced by diabetes. From the RARE imagings, voxel-based morphometry analyses using 3 tissue classes probability altas can detect subtle volume changes in gray and white matters in diabetic rats at 4w after STZ injections, with gray matter atrophy in cortex, amygdala (Amy), caudate putamen (Cpu), hippocampus (Hip), thalamus, periaqueductal gray matter (PAG), and white matter atrophy in cingulum (cg), corpus callosum (cc), external capsule (ec), internal capsule (ic), cerebral peduncle (cp), optic tract (opt), fimbria (fi).