Abstract #1007

Initial Application of PH-Weighted Imaging with Pulsed CEST to Image an Acute Ischemic Stroke Patient

Alan J. Huang¹,², Craig Jones¹,³, Richard Leigh⁴, Samson Jarso¹,³, Peter van Zijl¹,³

¹FM Kirby Research Center for Functional Brain Imaging, Johns Hopkins University, Baltimore, MD, United States; ²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; ³Russell Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States; ⁴Department of Neurology, Johns Hopkins University, Baltimore, MD, United States

We demonstrate the initial application of pH-weighted imaging with pulsed CEST to image the ischemic penumbra of an acute cerebral ischemic stroke patient. The magnetization transfer asymmetry ratio around 3.5 ppm was used to compare regions of interest between the patient and a healthy volunteer. The patient showed a region of reduced CEST contrast, which was attributed to tissue acidosis in the ischemic region. This region was larger than the diffusion impaired region but smaller than the perfusion impaired regions.