Hsiao-Ying Wey1, 2, Ghazwan M. Kroma3, Jinqi Li, 23, M Michelle Leland4, Lisa Jones4, Timothy Q. Duong, 23
1Department of Radiology, A. A. Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Charlestown, MA, United States; 2Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 3Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 4Department of Laboratory Animal Resources, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States
This study describes the development of a large non-human primate (baboon) stroke model (permanent and transient stroke) and the implementation of multiparametric MRI protocols to characterize the evolution of lesion volume, the perfusion-diffusion mismatch, quantitative CBF and ADC changes, and cerebral vascular reactivity. Improved understanding of the lesion evolution and perfusion-diffusion mismatch in clinically relevant model of stroke might provide important information to better guide clinical diagnosis, test novel interventions and improve treatment time windows.