Abstract #0859

Quantitative 2D Chemical Shift Imaging of Glutamate in Brain Tumour Patients

Bradford A. Moffat¹, Liubinas Simon², Katherine Drummond², Andrew Morokoff², Terrence O'Brien³, Chris Kokkinos⁴, Patricia M. Desmond¹

¹Radiology, University of Melbourne, Parkville, Victoria, Australia; ²Surgery, University of Melbourne, Parkville, Victoria, Australia; ³Neurology, University of Melbourne, Parkville, Victoria, Australia; ⁴Radiology, Royal Melbourne Hospital, Parkville, Victoria, Australia

Glutamate concentration in human brain tumours has been quantified from 2D CSI PRESS imaging. We present HPLC validation of this technique. A High Correlation with HPLC data suggests 2D CSI is an excellent biomarker of in vivo Glutamate concentrations.