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Abstract #0830

Strength of Connectivity to the Anterior Cingulate Predicts Processing Speed in Multiple Sclerosis

Katherine A. Koenig1, Erik B. Beall1, Jian Lin1, Blessy Mathew1, Lael Stone2, Robert Bermel2, Stephen Rao3, Bruce Trapp4, Micheal D. Phillips1, Mark J. Lowe1

1Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States; 2Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, United States; 3Schey Center for Cognitive Neuroimaging, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, United States; 4Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, United States


It has been shown that functional connectivity MRI (fcMRI) from the anterior cingulate (ACC) shows correlation with cognitive function in MS. In the current study, fcMRI from the ACC for 47 MS patients and 24 healthy controls was correlated with performance on the SDMT. In patients, SDMT performance was