Abstract #0804

Spontaneous Depolarization Waves in Medetomidine Sedated Sprague-Dawley Rats Detected by FMRI

Artem Shatillo¹, Joanna Huttunen¹, Antti Airaksinen¹, Juha-Pekka Niskanen¹,², Olli Grohn¹

¹Department of Neurobiology, University of Eastern Finland, Kuopio, Finland; ²Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

Spreading depolarization (SD) waves are typically observed only under pathophysiological conditions. We detected spontaneously occurring SDs in 9 Sprague-Dawley rats during 1 hour long BOLD fMRI study under medetomidine sedation. Total of 17 waves were detected lasting for 193.3 58.8 sec in one cortical ROI, propagating with speed of 2.930.6 mm/min. Observed propagation pattern and involvement of subcortical regions is atypical for classical spreading depolarization described in literature and needs further investigations.