Ashok Panigrahy1, 2, Lisa Paquette3, Marvin D. Nelson2, Jessica L. Wisnowski2, 4, Stefan Bluml2, 5
1Department of Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States; 2Department of Pediatric Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States; 3Division of Neonatology, Children's Hospital of Los Angeles, Los Angeles, CA, United States; 4Brain and Creativity Institute, University of Southern California, Los Angeles, CA, United States; 5Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States
Our study shows distinct metabolic differences in the CNS of neonates with congenital heart disease and prematurity including elevated myo-inositol in multiple regions of babies with congenital heart disease neonates and selective parietal white matter multi-metabolic hypermetabolism in the preterm neonates which may underlie patterns of poor cognitive outcome in these patients.