Abstract #0745

RF Power Dependence of Human Brain CEST, NOE & Metabolite MT Effects at 7T

Dapeng Liu¹, Jinyuan Zhou²,³, Rong Xue¹, Zhentao Zuo¹, Jing An⁴, Danny JJ Wang⁵

¹State Key Lab. of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; ²FM Kirby Center, Kennedy Krieger Institute, Baltimore, MD, United States; ³Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutes, Baltimore, MD, United States; ⁴Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China; ⁵Neurology, UCLA, Los Angeles, CA, United States

In this work we investigated the RF power dependence of the magnetization transfer (MT) asymmetry effects at 7T. The results suggest that at low B1, the nuclear Overhauser enhancement (NOE) and metabolite MT effects are the dominant source of MT asymmetry while at higher B1, the amide proton transfer (APT) effect becomes stronger and finally reverses the asymmetry plot. Our results suggest that MT asymmetry at 7T with low B1 may provide an approach for in vivo imaging of brain lipid (e.g., myelin).