Evaluation of Functional Connectivety in a Cold-Microtubule Deficient Mice Using Manganese Enhance Magnetic Resonance Imaging in vivo

Alexia Daoust¹, ², Emmanuel Luc Barbier¹, ², Annie Andrieux¹, ², Sylvain Bohic³, ⁴, Jean-Christophe Deloulme, ²³

Stable tubule only polypeptide deficient mice (STOP KO) are devoid of cold stable microtubule, which induces a synaptic deficit. In this study, we evaluate the cortical projections in these mice and in the corresponding wild type: functionally, using MEMRI (between 2 and 24h after intracortical injections) and structurally using gold staining histology. We observed that the functional deficits observed (long-range projections) are not correlated to structural deficit (reduction in tract size).