In Vivo GABA T2 Determination with J-Refocused Echo Time Extension at 7T

Anna Andreychenko¹, Dennis W.J. Klomp¹, Robin A. de Graaf², Peter R. Luijten¹, Vincent O. Boer¹

A method to measure T2 relaxation times when using spectral editing techniques is proposed. A spectrally selective refocusing pulse was incorporated into MEGA-sLASER editing technique to refocus J-modulation of the edited signal at different echo times. In this way the echo time can be arbitrary extended while preserving the shape of the edited signal. The efficiency of the method was demonstrated for in vivo creatine and GABA T2 measurements at 7T.