Abstract #0650

Increased FA in Acute TBI Rat Marmarau Model Followed by Decreased FA During Subacute Stage: A TBSS Study

Ramtilak Gattu¹, Randall R. Benson²,³, Zhifeng Kou⁴, Nisrine Zakaria⁵, Srinivasu Kallakuri⁵, Yimin Shen, John M. Cavanaugh⁵, Hardik J. Doshi⁵, Ewart M. Haacke⁶

¹Radiology, Wayne State university School of Medicine, Novi, MI, United States; ²Neurology, Wayne State university School of Medicine; ³Center for Neurological studies, Novi, MI, United States; ⁴Radiology and Biomedical Engg, Wayne State university; ⁵Biomedical Engineering, Wayne State university; ⁶Radiology and Biomedical Engg, Wayne State university School of Medicine

With the current study, our objective is to establish an advanced MR imaging-based version of the Marmarou rodent model of diffuse axonal injury.The focus of the current abstract is to examine DTI measures over the entire rat brain pre and post injury and over time (4 hrs to 7 days) to determine the natural history of fractional anisotropy (FA) at hyperacute, acute and subacute stages. Contradictory findings in the literature regarding FA measures acutely (increase vs. decrease) exist, highlighting the importance of controlled longitudinal studies to clarify this and complex issues were studied using TBSS in rats.