Abstract #0646

Globally Impaired Network of Anatomical Connectivity in Tuberous Sclerosis Complex Patients with Autism Spectrum Disorders

Benoit Scherrer¹, Mustafa Sahin¹, Caterina Stamoulis¹, Sanjay P. Prabhu¹, Alireza Akhondi-Asl¹, Simon K. Warfield¹

¹Radiology, Harvard Medical School, Children Hospital Boston, Boston, MA, United States

This study is to our knowledge the first to investigate with diffusion imaging the network of anatomical connectivity in tuberous sclerosis complex (TSC) patients and its relationship to autism spectrum disorder (ASD). Our results suggest that the network is globally significantly affected in TSC patients with ASD.