Abstract #0624

Pulmonary Parenchymal Blood Flow in Early Chronic Obstructive Pulmonary Disease (COPD): The MESA COPD Study

Katja Hueper¹,², Jens Vogel-Claussen¹,², Megha Parikh³, John HM Austin³, David A. Bluemke⁴, James Carr⁵, Thomas A. Goldstein⁶, Antoinette S. Gomes⁷, Eric A. Hoffman⁸, Joao AC Lima¹, Wendy Post¹, Martin Prince³, Kiang Liu⁵, Jan Skrok¹, Karol Watson⁷, Jie Zheng⁹, Graham Barr³

¹Johns Hopkins University, Baltimore, MD, United States; ²Hannover Medical School, Hannover, Germany; ³Columbia University Medical Center, New York, United States; ⁴Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States; ⁵Northwestern University, Chicago, IL, United States; ⁶Stanford University, Stanford, CA, United States; ⁷David Geffen UCLA School of Medicine, Los Angeles, CA, United States; ⁸University of Iowa Carver College of Medicine, Iowa City, IA, United States; ⁹Washington University School of Medicine, St Louis, MO, United States

Pulmonary vascular changes are known to occur in very severe chronic obstructive pulmonary disease (COPD). We hypothesized that pulmonary parenchymal blood flow and volume were decreased in mild-moderate COPD. Using pulmonary perfusion MRI we quantified perfusion parameters on a pixel-by-pixel basis in 100 patients with different severities of COPD and controls. Pulmonary parenchymal blood flow and volume were decreased in mild, moderate and severe COPD after adjustment for multiple parameters including the stroke volume, smoking status and packyears. These results support our hypothesis and demonstrate the value of pulmonary perfusion MRI for direct assessment of pulmonary vasculature in COPD.