Implementation & Validation of Time Encoded Pseudo Continuous Arterial Spin Labelling for Human Applications.

Wouter M. Teeuwisse¹, Ilya M. Veer, Andrew Webb¹, Matthias J.P. van Osch¹

In this study, time encoded pCASL is implemented on a clinical 3T scanner. Following a Hadamard encoding scheme, pCASL is modified such that the labelling period is split into blocks with varying label/control condition. This enables calculation of perfusion maps with 11 different post labelling delays from a single scan. Two versions were evaluated, one with blocks of constant duration and one with block duration adjusted for T1 decay of labelling signal. Resulting, whole brain, perfusion maps clearly show local and global variation in arterial filling and tissue enhancement over time. Quantitative ATT maps demonstrate the flow territory border zones.