Adam J. Jung1, Fergus V. Coakley2, Antonio C. Westphalen3, Daniel B. Vigneron3, John Kurhanewicz
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA , United States; 2Department of Radiology and Biomedical Imaging, University of California San Francisco; 3Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States
The primary socioeconomic challenge in caring for patients with prostate cancer is our limited ability to accurately characterize the disease as indolent or aggressive at the time of presentation, and stratify management from active surveillance through definitive surgery or radiation accordingly. A major contributing factor to this problem is the known inaccuracy in disease detection and characterization by systematic transrectal ultrasound-guided biopsy, even though this is the current standard of care for diagnosis. We demonstrate that multiparametric MRI supplemented by MRI-guided biopsy can improve both disease detection and characterization, and may ultimately improve our ability to deliver personalized patient care in men with prostate cancer.