Ivan Tkac1, Lori Zacharoff2, Janet M. Dubinsky2
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Department of Neuroscience, University of Minnesota, Minneapols, MN, United States
In Vivo 1H NMR spectroscopy at 9.T was used to investigate neurochemical changes in three different mouse models of Huntingtons disease; transgenic R6/2, knock-in Q140 and bacterial artificial chromosome transgenic BACHD mouse models. Substantial differences in metabolite age-dependent trajectories were observed between these mouse models of HD. Metabolite changes mostly localized in striatum of the Q140 mice more closely resembles phenotypes of the human HD. Therefore, the Q140 mouse model might be preferential for studies of HD and its treatment.