Voxel-Wise Estimation of M & CMRO2 at 7T

Emma Louise Hall¹, Ian D. Driver¹, Susan E. Pritchard¹, Penny A. Gowland¹, Susan T. Francis¹

The Davis model is widely used to estimate the change in CMRO₂ in response to a stimulus. This requires the measurement of CBF and BOLD in response to a stimulus and hypercapnia. Increased sensitivity at 7T allows voxelwise assessment of CBF and BOLD, and multiphase ASL allows transit time independent estimation of CBF. Here we estimate M and CMRO₂ for a motor task on a voxel-by-voxel basis compared to standard ROI analysis, for a CBF and BOLD ROI. A BOLD based ROI leads to overestimation of M and reduction in CMRO₂ compared to voxelwise analysis, and a CBF based ROI.