Mapping Brown Adipose Tissue Through Intermolecular Double-Quantum Magnetic Resonance Imaging at 7 Tesla

Jianfeng Bao¹, Xiaohong Cui¹, Zhenyao Zheng¹, Congbo Cai¹, Zhong Chen¹

Brown adipose tissue (BAT) has been found to be potential to combat against obesity and related diseases in adults, and has become a focus in biological and medical fields again. However, it is difficult to image BAT directly in vivo, especially when BAT mixes with other tissues. Here, we proposed a new method combining intermolecular double-quantum coherence with Dixon technique to map BAT only. The simulation and experimental results show that BAT can be imaged successfully at cellular scale. This new method may be significant in exploring the dynamic process of BAT in combating obesity.