Yi-Ou Li1, Sara LaHue1, 2, Roger Chen1, Shelly Cooper1, 2, John Yue1, 2, Geoffrey Manley2, Pratik Mukherjee1
1Radiology, University of California San Francisco, San Francisco, CA, United States; 2Neurosurgery, University of California San Francisco, San Francisco, CA, United States
Based on current studies of functional connectivity after traumatic brain injury (TBI), we focus on 14 brain regions and apply seed region correlation analysis to the resting state fMRI of 51 mild brain trauma patients one month after injury and 45 demographically matched healthy controls. The statistical tests on the brain connectivity maps reveal reduced functional connectivity of multiple networks, most prominently the default mode network and hippocampus; however, connectivity is increased in a motor-SMA network that includes the dACC. These initial results demonstrate that resting state fMRI has promise as an imaging biomarker for clinical outcome after mild TBI.