Abstract #0363

Absolute Quantification of in vivo Water & Fat Content

Yifan Cui¹, Issac Y. Yang², Trevor Wade², Curtis N. Wiens¹, Abraam S. Soliman³,⁴, Charles A. McKenzie,¹²

¹Physics and Astronomy, University of Western Ontario, London, Ontario, Canada; ²Medical Biophysics, University of Western Ontario, London, Ontario, Canada; ³Biomedical Engineering, University of Western Ontario, London, Ontario, Canada; ⁴Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada

Accurate measurement of in vivo fat fraction has been demonstrated with IDEAL. However, knowing the absolute (instead of relative) fat and water content is valuable for understanding the source of fat fraction changes. Existing methods for absolute fat and water quantification are limited to single coil data acquisition and have not been demonstrated in vivo. We have extended these methods with rapid B₁⁺ measurement and corrections for coil array sensitivity, validated the accuracy of fat and water content measurement with these corrections and demonstrated the use of this new method for in vivo imaging.