Serial Effects of Iodinated Contrast Media on the Renal Hemodynamics & Oxygenation as Evaluated by ASL & BOLD MRI

Jing Wang¹, Yudong Zhang², Xuedong Yang², Xiaoying Wang², Jue Zhang¹, ³, Jing Fang¹, ³

Contrast media is associated with several adverse effects, including contrast-induced nephropathy. We utilized noninvasive ASL and BOLD MRI to evaluate the serial effects of intravenous-injected iodinated CM on rabbit renal hemodynamics and oxygenation. Both FAIR-ASL and multiple-echo SPGR sequences were performed 24 hours before and 1, 24, 48 and 72 hours after injection to obtain serial renal blood flow and relative spin-spin relaxation rate (R2*). Iopamidol is associated with a relatively longer-term hypoperfusion in whole kidney and decreased oxygen level in the inner stripes of the outer medulla.