Adam
T. Eggebrecht1, Brian R. White1, Silvina L. Ferradal1,
2, Chunxiao Chen3, Yuxuan Zhan4, Abraham Z.
Snyder, 5, Hamid Dehghani6, Joe P. Culver7,
8
1Radiology, Washington University School of Medicine, St Louis, MO, United States; 2Biomedical Engineering, Washington University in St. Louis, St Louis, MO, United States; 3Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, China; 4School of Computer Science, University of Birmingham; 5Neurology, Washington University School of Medicine, St Louis, MO, United States; 6School of Computer Science, University of Birmingham, United Kingdom; 7Radiology, Washington University School of Medicine, Saint Louis, MO, United States; 8Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, United States
fMRI has commanded a dominant role in current neuroscience research, yet its use in neuro-scientific or bedside clinical studies has been limited because the current tools lack the combination of being portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging overcomes these obstacles, but, until recent advancements in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. We evaluate the image-quality of HD-DOT against fMRI using functional maps of the visual cortex as a benchmark and quantify localization error with center-of-mass and phase metrics. This work provides support for adoption of HD-DOT as a surrogate for fMRI.