Abstract #0273

Hyperpolarized 13C Imaging of Metabolic Remodeling in a Porcine Cardiac Ischemia-Reperfusion Model

Angus Z. Lau¹,², Albert P. Chen³, William Dominguez-Viqueira², Marie A. Schroeder²,⁴, Yiping Gu², Jennifer Barry², John Graham²,⁵, Nilesh Ghugre², Graham A. Wright¹,², Charles H. Cunningham¹,²

¹Dept. of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; ²Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada; ³GE Healthcare, Toronto, Ontario, Canada; ⁴Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; ⁵Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada

A dual respiratory and cardiac-gated, multi-slice, single-shot spiral frequency-specific 13C pulse sequence was used to characterize cardiac metabolic remodeling following acute myocardial infarction in vivo in a porcine ischemia-reperfusion model. We observed two distinct phenotypes, corresponding to myocardial stunning and infarction, with distinct metabolic remodeling patterns revealed by hyperpolarized 13C imaging. PDH flux was reduced following LAD occlusion, with recovery in stunned myocardium. Elevated myocardial lactate was observed in the peri-infarct region, presumably reflecting the potential viability of the myocardium in that area. This work may potentially enable a clinically feasible assessment of salvageable myocardium (the area-at-risk) in myocardial infarction.