Steady-State & Dynamic Susceptibility Contrast Using USPIOs in Humans

Thomas Christen¹, Deqiang Qiu¹, Wendy Wei Ni¹, Heiko Schmiedeskamp¹, Roland Bammer¹, Michael Moseley¹, Greg Zaharchuk¹

In this study, we acquired both steady-state and dynamic susceptibility CBV maps using ferumoxytol (an FDA-approved ultra-small paramagnetic iron oxide (USPIO) compound) in 4 volunteers and compared the quantitative values at different doses and spatial resolutions. The results show similar patterns between all the maps and average blood volumes that are consistent with prior literature values. The study suggests that high-resolution quantitative CBV maps can be obtained with the proposed steady-state approach and could be used to detect smaller lesions.