Sandeep K. Ganji1, Abhishek Banerjee1, Zoltan Kovacs1, Ivan E. Dimitrov1, 2, Ralph J. DeBerardinis3, Craig M. Malloy1, Bruce Mickey4, Robert Bachoo5, Elizabeth A. Maher6, Changho Choi1
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Philips Medical Systems, Cleveland, OH, United States; 3Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States; 4Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, United States; 5Neurology, UT Southwestern Medical Center, Dallas, TX, United States; 6Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States
2-hydroxyglutarate (2HG) is known to accumulate in a vast majority of low grade gliomas and secondary glioblastomas. We report in vivo spectroscopic imaging of 2HG using an optimized echo-time PRESS-based localization method at 3T in patients with gliomas. We present phantom and in vivo healthy volunteer validation data and show the elevated 2HG levels in tumor patients. Metabolite concentration maps are presented.