Imaging of Prostate Cancer Metabolic Heterogeneity with CEST & MT MRI

Kejia Cai¹, He N. Xu, Anup Singh¹, Mohammad Haris¹, Ravinder Reddy¹, Lin Z. Li

Here we report the preliminary data on chemical exchange saturation transfer (CEST) & magnetization transfer (MT) magnetic resonance imaging (MRI) and redox scanning of two aggressive human prostate tumor lines (PC-3 and DU-145) xenografted in athymic nude mice. The results obtained by these methods appeared to be consistent with all showing higher level of heterogeneity in DU-145 tumors than in PC-3 tumors at this stage of tumor progression. MT and CEST MRI method could serve as a surrogate metabolic imaging biomarkers for redox imaging of tumor metastatic potential.