Shaolin Yang1, 2, Olusola Ajilore1, Minjie Wu1, Melissa Lamar1, Anand Kumar1
1Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States
Type 2 diabetes and major depression are disorders that are mutual risk factors. In this study, we examined the brain biophysical abnormalities in patients with both type 2 diabetes and major depression using magnetization transfer imaging. The subject population consisted of 4 groups: patients with type 2 diabetes and major depression, patients with either disease alone, and controls. We found the magnetization transfer ratio (MTR) in right head of caudate nucleus was significantly lower in patients with both diseases when compared with controls and the MTRs in patients with either disease alone were also significantly lower but with intermediate values.