Ming Zhang1, Pan Lin2, Chenwang Jin1, Cuiping Mao1, Chen Niu1, ZhiGang Min1, Jingxia Dang3, Qiaoting Jin3, Xin Liu2
1Department of Medical Imaging, the First Affiliated Hospital of Medical College,Xian Jiaotong University, Xi'an, Shaanxi, China; 2Key Laboratory of Biomedical Information Engineering of Education Ministry, Xian Jiaotong University, Xi'an, Shaanxi, China; 3Department of Neurology, the First Affiliated Hospital of Medical College,Xian Jiaotong University, Xi'an, Shaanxi, China
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterized by deficits in motor systems.Striatum-motor network has found to play important role in motor control.Whether the fluctuations of resting fMRI signal within striatum-motor network funtional connectivity is associated with abnormal neuronal activity remains unclear.In this study, we specifically investigate wheather patients with ALS is associated with dysfunction of interregion functional connectivity in striatum-motor network that support motor function.