Abstract #0020

In Vivo Hydrogen-1, Sodium-23, Phosphorus-31, and Potassium-39 Magnetic Resonance Imaging After Middle Cerebral Artery Occlusion

Friedrich Wetterling¹, Nagesh Shanbhag², Lothar Schilling², Stefan Kirsch¹, Lothar Rudi Schad¹

¹Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; ²Division of Neurosurgical Reasearch, Heidelberg University, Mannheim, Germany

In the current feasibility study, four single-tuned surface resonators for Hydrogen-1 (1H), Sodium-23 (23Na), Phosphorus-31 (31P), and Potassium-39 (39K) MRI were used in conjunction with a linearly-polarized 1H-volume resonator to examine in vivo brain tissue after induction of focal ischaemia. The 1H-Apparent diffusion coefficient, as well as the relaxation time weighted 1H-, 23Na-, 31P, and 39K-signals were analysed and expressed as a percentage change compared to contralateral normal tissue. We conclude that multi-parameter X-nuclei MRI at 9.4T provides a promising tool to study metabolic and ion concentration changes after cerebral artery occlusion non-invasively with sufficient spatial and temporal resolution.