Haosen Zhang1, Kevin Hitchens1,
Qing Ye1, Erik B. Schelbert2, Chien Ho1
1Pittsburgh NMR Center for
Biomedical Research, Department of Biological Science, Carnegie Mellon
University, Pittsburgh, PA, United States; 2Department of
Medicine, University of Pittsburgh, Pittsburgh, PA, United States
In this study, an inversion recovery (IR)-prepared segmented gradient echo sequence was developed to sample the T1 recovery curve in Look-Locker scheme at 7 T. Via a multi-variable regression algorithm corrected for the saturation effect induced by the -train, we have obtained more accurate T1 values than with the conventional three-parameter fit (average error of -0.53% vs. -5.4% separately, compared to T1s measured with IR-SE) in agarose phantoms simulating human myocardium and blood.