Vincent Gras1, Zaheer Abbas2,
Anna-Maria Oros-Peusquens3, Klaus Hans Manfred Mllenhoff3,
Fabian Keil3, Miriam Rabea Kubach1, Nadim Jon Shah1,4
1Institute of Neuroscience
& Medicine 4, Medical Imaging Physics, Forschungszentrum Jlich GmbH,
Jlich , Germany; 2Institute of Neuroscience & Medicine 4, Medical
Imaging Physics, Forschungszentrum Jlich
GmbH, Jlich , Germany; 3Institute of Neuroscience &
Medicine 4, Medical Imaging Physics, Forschungszentrum Jlich GmbH, Jlich,
Germany; 4Faculty of Medicine, Department of Neurology, RWTH
Aachen University, Aachen, Germany
A 1.5T and 3T quantitative water content imaging protocol is proposed, extending a previously developed method, suited to 1.5T only. The benefit of working at 3T is a noticeable gain in SNR compared to 1.5T, although refinements are needed for the accuracy to be preserved. The gradient echo approach, envisaged in this work, allows for the detection of myelin water, exhibiting short relaxation times. Furthermore, the required short scanning time, 15 minutes, is particularly suited to the clinical practice. The accuracy of the method is evaluated to 2%, making this method eligible for the detection of cerebral oedema of various origins. This method is presented and in vivo results at 1.5T and 3T are shown.