Abstract #4341

New Insight Into Mechanism of Epileptogenesis with Dynamic T1 Contrast Perfusion MRI in Calcified Neurocysticercosis

Rakesh Kumar Gupta¹, Rishi Awasthi¹, Prativa Sahoo², Avantika Verma³, Vimal Kumar Paliwal⁴, Ramesh Venkatesan⁵, Kashi Nath Prasad³, Ram K. S. Rathore²

¹Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; ²Mathematics & Statistics, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India; ³Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; ⁴Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; ⁵Wipro-GE Healthcare, Bangalore, Karnataka, India

DCE-MRI was performed on 30 patients with Neurocysticercosis (NCC), cysts which were found to be calcified on imaging. Various perfusion indices were analyzed and it was found that Kep, ve and MMP-9 expression were significantly higher in symptomatic as compared to asymptomatic patients. Moreover, a strong correlation of serum MMP-9 with Kep portend that Kep can be used to differentiate between symptomatic and asymptomatic patients.