Time Course of Diffusion Restriction in Neonates with Hypoxic Ischemic Encephalopathy Treated with Hypothermia

Nathalie Bednarek¹, Jared Wilkinson¹, Amit Mathur¹, Preethi Srinivasakumar¹, Jeff Neil¹, Terrie Inder¹, Joshua Shimony¹

Hypoxic ischemic encephalopathy (HIE) in infants is often treated with hypothermia during the early days of life. Knowledge of the time course of diffusion changes after ischemia is critical for accurate radiologic interpretation and deciding the optimal time to order the MRI. This study demonstrates that the time course of diffusion changes in infants with HIE treated with hypothermia is different from those not treated with hypothermia.