Rajan Jain1,2, Jayant Narang1,
Jack P. Rock2, Lisa Scarpace2, Lonni Schultz3,
Syed Ali Arbab4, Jorge Gutierrez5
1Neuroradiology, Henry Ford
Health System, Detroit, MI, United States; 2Neurosurgery, Henry
Ford Health System, Detroit, MI, United States; 3Epidemiology
& Biostatistics, Henry Ford Health System, Detroit, MI, United States; 4Radiology,
Henry Ford Health System, Detroit, MI, United States; 5Neuropathology,
Henry Ford Health System, Detroit, MI, United States
The purpose of this study was to correlate the status of MRI contrast enhancement with various immuno-histological vascular parameters such as microvascular cellular proliferation (MVCP), microvascular density (MVD), VEGFR-2 (vascular endothelial growth factor receptor-2) expression, WHO grade and CT perfusion parameters using image-guided biopsy specimens. Functional imaging like perfusion studies are being increasingly used in todays clinical practice to predict tumor grade and angiogenesis. But availability and expertise in interpretation are important limiting factors in their widespread use. Our study shows that MRI contrast enhancement correlates well with various immune-histological markers as well as CT perfusion parameters and can help assess regional heterogeneity of tumor angiogenesis.