Abstract #4246

Morphometric Changes Detected in Hepatits C (HCV) & HCV/HIV Co-Infected Adults

Manoj K. Sarma¹, M. Albert Thomas¹, Rajakumar Nagarajan¹, April Thames², Steven Castellon^3,4, Elyse Singer⁵, Jason Smith⁴, Jonathan Truong⁶, Homayoon Khanlou⁷, Ann Ragin⁸, Charles Hinkin^3,4

¹Radiological Sciences, UCLA, Los Angeles, CA, United States; ²Psychiatry, UCLA School of Medicine, Los angeles, CA, United States; ³Psychiatry, UCLA School of Medicine, Los Angeles, CA, United States; ⁴VA Greater Los Angeles Healthcare Service, Los Angeles, CA, United States; ⁵Neurology, UCLA School of Medicine, Los Angeles, CA, United States; ⁶Kaiser Permanente Lancaster, CA, United States; ⁷AIDS Healthcare Foundation, Los Angeles, CA, United States; ⁸Radiology, Northwestern University, Chicago, IL, United States

Both Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) have same routes of transmission, but little is known about how the co-infection effect the cortex. We have done a cortical surface-based analysis of the whole cortical mantle to investigate the cortical thickness/volume and cerebral white matter (WM) volume across a group of HCV/HIV co-infected and HCV mono-infected adult patients. Our results showed widespread brain regions with thinning of cortical thickness (CT) in HCV/HIV co-infected adults relative to HCV mono-infected. Thickening of CT is also seen in some regions. We also observed cerebral WM volume and cortical volume changes.