Abstract #4191

Cortical Metabolic Alterations Induced by Genetic Redox Deregulation in GCLM KO Mice & the Protective Effect of N-Acetylcysteine Treatment: Relevance for Schizophrenia

Joao M. N. Duarte^1,2, Anita Kulak³, Kim Q. Do³, Rolf Gruetter^1,4

¹Laboratory for functional & metabolic imaging, Center for Biomedical Imaging, Ecole Polytechnique, Lausanne, Vaud, Switzerland; ²Faculty of Biology & Medicine, University of Lausanne, Lausanne, Vaud, Switzerland; ³Center for Psychiatric Neuroscience, Univ. Hosp. Lausanne, Switzerland; ⁴Department of Radiology, Universities of Lausanne & Geneva, Lausanne, Switzerland

Schizophrenia is associated with genes of glutathione (GSH) metabolism. GSH is decreased in cerebrospinal fluid and prefrontal cortex of schizophrenia patients. We now evaluated the role of genetic-induced redox deregulation in brain metabolism and investigated whether partially restoring the redox balance with the GSH precursor and antioxidant N-acetylcysteine (NAC) could normalize impaired metabolism.