Abstract #4177

Metabolic Changes in the Focal Brain Ischemia in Rats Treated with Human Induced Pluripotent Cell-Derived Neural Precursors

Daniel Jirak^1,2, Karolina Turnovcova³, Nataliya Kozubenko³, Pavla Jendelova³, Milan Hajek^1,2

¹Department of Diagnostic & Interventional Radiology, Institute for Clinical & Experimental Medicine, Prague, Czech Republic; ²Center for Cell Therapy & Tissue Repair, Prague, Czech Republic; ³Institute of Experimental Medicine, Czech Republic

We describe the use of human-induced pluripotent cell-derived neural progenitors for transplantation into the rat brain after temporary middle cerebral artery occlusion. The aim of our study was to determine metabolic changes by 1H MR spectroscopy in the striatal tissue after focal brain ischemia during four months.