Default-Mode Resting Network in Mild Traumatic Brain Injury (MTBI)

Yongxia Zhou¹, Lin Tang¹, Daniel K. Sodickson¹, Joseph Reaume¹, Laura Miles¹, Robert I. Grossman¹, Yulin Ge¹

We used resting state fMRI to investigate the fronto-posterior connections; especially the posterior cingulate and medial frontal nodes contained in default mode networks (DMNs). Three different methods including seeding-based PCC connectivity, single-subject Informax ICA based and probabilistic multi-session temporal concatenation based group PICA were used to compare 23 MTBI patients to 18 controls. All three methods showed increased DMNs in medial frontal regions and slightly decreased DMNs in doros-lateral prefrontal regions in MTBI patients, suggesting that the MTBI patients might recruit more of medial orbito-frontal regions to mediate the resting networks when dorsolateral prefrontal connectivity is decreased due to injury.