Olivier Baldent1, Soraya El Sankari2,
Catherine Gondry-Jouet3, Anthony Fichten4, Olivier
Pottie1, Roger Bouzerar1, Jean-Marie Serot5,
Olivier Godefroy2, Herv Deramond3, Marc-Etienne Meyer1
1Image Processing,
University Hospital Jules Verne, Amiens, Picardie, France; 2Neurology,
University Hospital Jules Verne, Amiens, Picardie, France; 3Radiology,
University Hospital Jules Verne, Amiens, Picardie, France; 4Neurosurgery,
University Hospital Jules Verne, Amiens, Picardie, France; 5Geriatry,
University Hospital Jules Verne, Amiens, Picardie, France
Our purpose was to evaluate PC-MRI on intracranial flows in Mild Cognitive Impairment (MCI) and Alzheimer Disease (AD). Patients underwent 3T MRI with 2D Phase Contrast (2D-PCMRI) pulse sequences to evaluate CSF oscillations and cerebral blood flows. Results were compared to normal values in age matched elderly healthy volunteers, and to Chronic Adult Hydrocephalus (CAH) patients. Arterial flow was significantly increased in MCI patients. Aqueductal CSF flow was normal in AD, hyper dynamic in MCI patients but less than in CAH patients. In conclusion this study highlights the interest of 2D-PCMRI and supports the vascular theory of AD pathophysiology